2004年7月在东北师范大学获得博士学位，专业为遗传与细胞生物学。2004年7月至2009年12月留东北师范大学生命科新京澳门葡萄城任教，历任讲师、副教授；2009年12月至2012年10月，在中国科新京澳门葡萄城北京化学研究所从事生物医学和化学的交叉领域研究工作，为副研究员。曾于2007年11月至2009年6月，在美国匹兹堡大学医学研究中心从事博士后研究工作；2012年10月至2016年5月，在美国西北大学医新京澳门葡萄城从事研究工作，先后为Visiting Scholar和Research Associate。两次在美期间，主要从事造血干细胞发育、血液系统肿瘤的发病机制和靶向性治疗研究。2016年8月调入新京澳门葡萄城任教授。
■血液系统肿瘤发生的细胞和分子调节机制研究。骨髓异常增殖性肿瘤（MPNs）的信号转导机制和靶向性治疗研究；造血干细胞和前体细胞（Megakaryocyte)异常分化分子机制及其与造血微环境的作用研究。高危骨髓增生异常综合征（MDS）患者红系异常发育分子机制研究；早期T淋巴细胞白血病（EPT-ALL）T细胞异常发育规律和机制研究。
■肺腺癌的耐药遗传进化和候选分子标志物研究。
■三阴性乳腺癌的免疫调节机制研究。
■生物医学和化学交叉领域的研究。利用新型的化学材料建立荧光检测系统，进行新冠病毒特定序列探测，肿瘤患者基因突变和甲基化早期筛查、定量累积检测、临床相关性分析和抗肿瘤研究。
1.Leukemia stem/progenitor cell differentiation and fate decision.
2.Targeting myeloid leukemia with small molecules.
3.Molecular diagnosis and drug resistance biomarkers for in leukemia and lung cancer.
4.Interdisciplinary biomedical research with chemical tools
1) Application of novel flurensent conjugated polymers and their self-assemble systems detecting gene mutations, methylation and pathogenic microorgnisms
2) Investigation of conjugated polymer-based and LDL-coated small chemical inhibitors in leukemia cells and animal models
EDUCATION EXPERIENCE
Institute |
Degree |
Year |
Field |
Institute of Genetics & Cytology Northeast Normal University Jilin Province, P. R. China |
Ph. D. |
09/01-07/04 |
Cytology |
Dept. of Biochemistry & Molecular Biology, Jilin University, Jinlin Province, P. R. China |
M. S. |
09/98-07/01 |
BasicMedical Science |
PROFESSIONAL EXPERIENCE
Position |
Year |
Institute |
Professor |
08/2016-present |
Life Science School, Beijing Normal University, Beijing, China |
Research Associate Visiting Scholar |
11/12-05/2016 |
Robert H Lurie Medical Research Center, Northwestern University, Chicago, IL |
Associate Professor |
12/09-04/13 |
Institute of Chemistry, Chinese Academy of Sciences, Beijing, China |
Postdoctoral fellow |
11/07-06/09 |
Division of Hematology/Oncology |
Associate Professor |
01/07- 12/09 |
Institute of Genetics & Cytology Northeast Normal University Jilin Province, China |
Instructor |
7/04- 12/06 |
Institute of Genetics & Cytology Northeast Normal University Jilin Province, P. R. China |
PUBLICATIONS
2024
1. THE TREATMENT LANDSCAPE OF TRIPLE-NEGATIVE BREAST CANCER. HU Y, WANG C, LIANG H, LI J, YANG Q*. MED ONCOL. 2024 41(10):236.
2.CURRENT STATUS AND NEW EXPERIMENTAL DIAGNOSTIC METHODS OF INVASIVE FUNGAL INFECTIONS AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION. TANG Z, WANG H, LIU Y, WANG C, LI X, YANG Q*. ARCH MICROBIOL. 2024 206(5):237.
2023
1.FASUDIL PROMOTES POLYPLOIDIZATION OF MEGAKARYOBLASTS IN AN ACUTE MEGAKARYOCYTE LEUKEMIA MODEL. HE B, WANG C, NIU J, WANG F, ZHANG Y, GAO Y, YANG Q*. NAUNYN SCHMIEDEBERGS ARCH PHARMACOL. 2023 396(11):3101-3110.
2.HEAT SHOCK PROTEIN 90 INHIBITORS INDUCE CELL DIFFERENTIATION VIA THE UBIQUITIN-DEPENDENT AURORA KINASE A DEGRADATION IN A MPLW515L MOUSE MODEL OF PRIMARY MYELOFIBROSIS. WANG F, ZHANG H, HE B, LIU Z, WU X, LIU Y, XU X, GOU X, WANG H, YANG Q*. HEMATOL ONCOL. 2023 41(3):474-486.
3. DIFFERENTIATION THERAPY FOR MURINE MYELOFIBROSIS MODEL WITH MLN8237 LOADED LOW-DENSITY LIPOPROTEINS*. HE B, WANG C, WANG F, TIAN L, WANG H, FU C, LIU J, XI C, ZHU C, YANG Q*. J CONTROL RELEASE. 2023 356:554-566.
4. UPDATES IN LABORATORY IDENTIFICATION OF INVASIVE FUNGAL INFECTION IN NEONATES. HE B, YANG Q*. MICROORGANISMS. 2023 APR 11(4):1001.
2022
1. COMBINATION OF AURKA INHIBITOR AND HSP90 INHIBITOR TO TREAT BREAST CANCER WITH AURKA OVEREXPRESSION AND TP53 MUTATIONS. WANG F, ZHANG H, WANG H, QIU T, HE B, YANG Q*. MED ONCOL. 2022 SEP 39(12):180.
2. STATE-OF-THE-ART REVIEW ON MYELOFIBROSIS THERAPIES. WANG F, QIU T, WANG H, YANG Q*. CLIN LYMPHOMA MYELOMA LEUK. 2022 22(5):E350-E362.
2021
A RAPID, VISIBLE, AND HIGHLY SENSITIVE METHOD FOR RECOGNIZING AND DISTINGUISHING INVASIVE FUNGAL INFECTIONS VIA CCP-FRET TECHNOLOGY. YANG Q, HE B, CHEN C, WANG H, LI W, XUE X, QIU T, HAO X, LV F, WANG S*. ACS INFECT DIS. 2021 OCT 7(10):2816-2825.
2020
CRUCIAL ROLE OF HISTONE DEACETYLASE SIRT1 IN MYELOID-DERIVED SUPPRESSOR CELL-MEDIATED REPROGRAMMING OF CD4+ T-CELL DIFFERENTIATION. DONG L, BI Y, JIA A, YU Q, WANG Y, WANG Y, YANG Q, CAO Y, HE Y, LIU R, LI Y, LIU G*. CELL MOL IMMUNOL. 2020 17(7):785-787.
2019
ACTIVATION OF JAK/STAT SIGNALING IN MEGAKARYOCYTES SUSTAINS MYELOPROLIFERATION IN VIVO WOODS B, CHEN W, CHIU S, MARINACCIO C, FU C, GU L, BULIC M, YANG Q, ZOUAK A, JIA S, SURANENI PK, XU K, LEVINE RL, CRISPINO JD, WEN QJ*. CLIN CANCER RES. 2019 25(19):5901-5912.
2017
1.ANP32A DYSREGULATION CONTRIBUTES TO ABNORMAL MEGAKARYOPOIESIS IN ACUTE MEGAKARYOBLASTIC LEUKEMIA. SUN X, LU B, HAN C, QIU W, JIN Q, LI D, LI Q, YANG Q, WEN Q*, OPAL P, KINI AR, CRISPINO JD*, HUANG Z*. BLOOD CANCER J. 2017 7(12):661.
2.DOWNREGULATION OF GATA1 DRIVES IMPAIRED HEMATOPOIESIS IN PRIMARY MYELOFIBROSIS. GILLES L, ARSLAN AD, MARINACCIO C, WEN QJ, ARYA P, MCNULTY M, YANG Q, ZHAO JC, KONSTANTINOFF K, LASHO T, PARDANANI A, STEIN B, PLO I, SUNDARAVEL S, WICKREMA A, MIGLIACCIO A, GURBUXANI S, VAINCHENKER W, PLATANIAS LC, TEFFERI A, CRISPINO JD*. J CLIN INVEST. 2017 127(4):1316-1320.
3.KINASE SIGNALING AND TARGETED THERAPY FOR PRIMARY MYELOFIBROSIS. YANG Q, CRISPINO JD, WEN QJ*. EXP HEMATOL. 2017 48:32-38.
2016
TYROSINE 625 PLAYS A KEY ROLE AND COOPERATES WITH TYROSINE 630 IN MPL W515L-INDUCED SIGNALING AND MYELOPROLIFERATIVE NEOPLASMS. YU C, YANG Q(CO-FIRST AUTHOR), CHEN Y, WANG D, LEVINE R, CRISPINO J, WEN Q*, HUANG Z*. CELL BIOSCI. 2016 6:34.
2015
TARGETING MEGAKARYOCYTIC-INDUCED FIBROSIS IN MYELOPROLIFERATIVE NEOPLASMS BY AURKA INHIBITION. WEN QJ, YANG Q (CO-FIRST AUTHOR), GOLDENSON B, MALINGE S, LASHO T, SCHNEIDER RK, BREYFOGLE LJ, SCHULTZ R, GILLES L, KOPPIKAR P, ABDEL-WAHAB O, PARDANANI A, STEIN B, GURBUXANI S, MULLALLY A, LEVINE RL, TEFFERI A, CRISPINO JD*. NAT MED. 2015 21(12):1473-1480.
2013
1.CONJUGATED POLYMER-COATED BACTERIA FOR MULTIMODAL INTRACELLULAR AND EXTRACELLULAR ANTICANCER ACTIVITY. ZHU C, YANG Q*, LV F, LIU L, WANG S*. ADV. MATER. 2013 25: 1203-1208.
2.PREPARATION AND OPTICAL PROPERTY OF NEW FLUORESCENT NANOPARTICLES. HUI CHONG CHUNLEI ZHU JINZHAO SONG LIHENG FENG YANG Q*, LIU L, FENGTING LV SHU WANG* MACROMOL. RAPID COMMUN. 2013 34: 736-774.
3.WATER-SOLUBLE CONJUGATED POLYMERS FOR IMAGING, DIAGNOSIS, AND THERAPY. ZHU C, LIU L, YANG Q, LV F, WANG S*. CHEM REV. 2012 112(8): 4687-4735.
4.DELETION OF THE RNA-EDITING ENZYME ADAR1 CAUSES REGRESSION OF ESTABLISHED CHRONIC MYELOGENOUS LEUKEMIA IN MICE. STEINMAN RA, YANG Q, GASPARETTO M, ROBINSON LJ, LIU X, LENZNER DE, HOU J, SMITH C, WANG Q*. INT J CANCER. 2013 APR 15;132(8):1741-1750.
2012
1.DETECTION AND DIFFERENTIAL DIAGNOSIS OF COLON CANCER BY A CUMULATIVE ANALYSIS OF PROMOTER METHYLATION. YANG Q, DONG Y, WU W, ZHU C, CHONG H, LU J, YU D, LIU L, LV F, WANG S*. NAT COMMUN. 2012 3: 1206.
2.POLYMER-DRUG CONJUGATES FOR INTRACELLAR MOLECULE-TARGETED PHOTOINDUCED INACTIVATION OF PROTEIN AND GROWTH INHIBITION OF CANCER CELLS. WANG B, YUAN H, ZHU C, YANG Q* , LV F, LIU L, WANG S*. SCIENTIFIC REPORTS 2012 2 766.
3.VISUAL DETECTION OF DNA MUTATION USING MULTICOLOR FLUORESCENT CODING. SONG J, YANG Q*, LV F, LIU L, WANG S*. ACS APPL MATER INTERFACES. 2012 4(6): 2885-2890.
4.WATER-SOLUBLE CONJUGATED POLYMERS FOR IMAGING, DIAGNOSIS, AND THERAPY. ZHU C, LIU L, YANG Q, LV F, WANG S*.CHEM REV. 2012 112 4687-4735.
5.CONJUGATED POLYMER NANOPARTICLES FOR LIGHT-ACTIVATED ANTICANCER AND ANTIBACTERIAL ACTIVITY WITH IMAGING CAPABILITY. CHONG H, NIE C, ZHU C, YANG Q*, LIU L, LV F, WANG S* LANGMUIR, 2012 28 2091-2098.
2011
1.RAPID SIMPLE AND HIGH-THROUGHPUT ANTIMICROBIAL SUSCEPTIBILITY TESTING AND ANTIBIOTICS SCREENING. ZHU C, YANG Q*, LIU L, WANG S*. ANGEW. CHEM. INT. ED. 2011 50 9607-9610.
2.MULTIFUNCTIONAL CATIONIC POLY(P-PHENYLENE VINYLENE) POLYELECTROLYTES FOR SELECTIVE RECOGNITION IMAGING AND KILLING OF BACTERIA OVER MAMMALIAN CELLS. ZHU C, YANG Q*, LIU L, LV F, LI S, YANG G, WANG S*. ADV. MATER. 2011 23 4805-4810.
3.A SIMPLE AND SENSITIVE METHOD FOR DETECTING POINT MUTATIONS OF EPIDERMAL GROWTH FACTOR RECEPTOR USING CATIONIC CONJUGATED POLYMERS. YANG Q *, QIU T, WU W, ZHU C, LIU L, YING J *, WANG S *. ACS APPLIED MATERIALS & INTERFACES 2011 3 4539-4545.
4.A POTENT FLUORESCENT PROBE FOR THE DETECTION OF CELL APOPTOSIS. ZHU C, YANG Q*, LIU L, WANG S *. CHEM. COMMUN. 2011 47 5524-5526.
5.VISUAL OPTICAL DISCRIMINATION AND DETECTION OF MICROBIAL PATHOGENS BASED ON DIVERSE INTERACTIONS OF CONJUGATED POLYELECTROLYTES WITH CELLS. ZHU C, YANG Q*, LIU L, WANG S*. J. MATER. CHEM. 2011 21 7905-7912.
6.DIRECT ENERGY TRANSFER FROM CONJUGATED POLYMER TO DNA INTERCALATED DYE: LABEL-FREE FLUORESCENT DNA DETECTION. WANG B, YANG Q*, LIU L, WANG S *. COLLOIDS SURF. B: BIOINTERFACES 2011 85 8-11.
7.DEVELOPMENT OF FILM SENSORS BASED ON CONJUGATED POLYMERS FOR COPPER (II) ION DETECTION. LV F, FENG X, TANG H, LIU L, YANG Q, WANG S *. ADV. FUNCT. MATER. 2011 21 845-850.
8.DESIGN GUIDELINES FOR CONJUGATED POLYMERS WITH LIGHT-ACTIVATED ANTICANCER ACTIVITY. XING C, LIU L*, YANG Q, WANG S*, BAZAN G C*. ADV. FUNCT. MATER. 2011 21 4058-4067.
9.DUAL-AMPLIFIED SENSITIVE DNA DETECTION BASED ON CONJUGATED POLYMERS AND RECYCLABLE AUTOCATALYTIC HYBRIDIZATION OF DNA. FENG X, LIU L , YANG Q, WANG S *. CHEM. COMMUN. 2011 47 6783-5785.
10.SYNTHESIS OF AMPHIPHILIC POLYTHIOPHENE FOR CELL IMAGING AND MONITORING CELLULAR DISTRIBUTION OF CISPLATIN ANTICANCER DRUG. TANG H, XING C, LIU L*, YANG Q, WANG S*. SMALL 2011 7 1464-1470.
11.TETRAACENAPHTHOPORPHYRIN: A PI-CONJUGATED PORPHYRIN WITH EFFICIENT LIGHT-ACTIVIATED ANTICANCER ACTIVITY. YANG G, LIU L*, YANG Q, WANG S* CHEM. ASIAN J. 2011 6 1147-1150.
12.CONJUGATED POLYMERS FOR SENSITIVE CHEMICAL SENSORS. ZHU C, YANG Q*, LIU L, WANG S*. PROGRESS IN CHEMISTRY 2011 23 1993-2002
2010
1.SYNTHESIS AND CHARACTERIZATION OF DEGRADABLE WATER-SOLUBLE FLUORESCENT POLYMERS. CHONG H, DUAN X, YANG Q *, LIU L, WANG S*. MACROMOLECULES 2010 43 10196-10200.
2.CONJUGATED POLYMER NANOPARTICLES FOR DRUG DELIVERY AND IMAGING. FENG X, LV F, LIU L*, TANG H, XING C, YANG Q, WANG S*. ACS APPL. MATER. INTERFACES 2010 2 2429-2435.
3.WATER-SOLUBLE CONJUGATED POLYMERS FOR FLUORESCENT ENZYME ASSAYS. FENG F, LIU L, YANG Q, WANG S *. MACROMOL. RAPID COMMUN. 2010 31 1405-1421.
4.A CONJUGATED POLYMER-GD(III) COMPLEX AS PH SENSITIVE CONTRAST AGENT IN MAGNETIC RESONANCE IMAGING. XU Q, LIU L*, ZHU L, YU M, YANG Q, WANG S*. FRONT. CHEM. CHINA 2010 5 166-170.
