烟台大学生物化学学士（1997），北京大学神经生理学硕士（2000），美国马里兰大学帕克分校神经与认知生物学博士（2007）。之后在美国天普大学Gill实验室先后以博士后及助理科学家的身份工作（2007-2013）。2013年5月正式入职新京澳门葡萄城抗性基因资源与分子发育北京市重点实验室，并入选教育部2013年度“新世纪人才支持计划”，获得了国家自然科学基金面上、重大研发计划、国际合作重点项目以及科技部重大研究计划等的资助
课题组研究领域为钙信号转导机制及其生理病理作用。近年主要关注细胞器（内质网-质膜）互作过程中的钙信号通路，致力于揭示STIM-Orai蛋白介导的钙池操纵钙内流（SOCE）的激活及调控机制。还合作开发各种钙探针，以及光遗传及光化学工具，进而利用各种活细胞荧光成像技术，全细胞膜片钳技术，蛋白邻近标记技术，CRISPR基因编辑及表达调控技术，以及光遗传学技术等，来检测及操纵细胞或模式生物在病理过程中失衡的钙稳态，进而探究钙信号在老年痴呆等神经退行性疾病中的防治作用。
代表性论著(#: 共同第一作者；*: 共同通讯作者) ：
1. Zhang Z#, Zhou H#, Gu W#, Wei Y, Mou S, Wang Y*, Zhang J*, Zhong Q*. (2024) CGI1746 targets σ1R to modulate ferroptosis through mitochondria- associated membranes. Nat Chem Biol. doi: 10.1038/s41589-023-01512-1.
2. Li J#, Shang Z#, Chen JH#, Gu W#, Yao L#, Yang X, Sun X, Wang L, Wang T, Liu S, Li J, Hou T, Xing D, Gill DL, Li J, Wang SQ, Hou L, Zhou Y*, Tang AH*, Zhang X*, Wang Y*. (2023) Engineering of NEMO as calcium indicators with large dynamics and high sensitivity. Nat Methods. 20(6):918-924.3. Xie J#, Ma G#*, Zhou L#, He L, Zhang Z, Tan P, Huang Z, Fang S, Wang T, Lee YT, Wen S, Siwko S, Wang L, Liu J, Du Y, Zhang N, Liu X, Han L, Huang Y, Wang R, Wang Y*, Zhou Y*, Han W*. (2022) Identification of a STIM1 Splicing Variant that Promotes Glioblastoma Growth. Adv Sci (Weinh). 9(11):e2103940. doi: 10.1002/advs.202103940.
4. He L#, Wang L#, Zeng H, Tan P, Ma G, Zheng S, Li Y, Sun L, Dou F, Siwko S, Huang Y*, Wang Y*, Zhou Y*. (2021) Engineering of a bona fide light-operated calcium channel. Nature Communications. 12(1):164. doi: 10.1038/s41467-020-20425-4
5. Yang X#, Ma G#, Zheng S#, Qin X, Li X, Du L, Wang Y*, Zhou Y*, Li M*. (2020) Optical control of CRAC channels using photoswitchable azopy-razoles. J Am Chem Soc., 142(20):9460-9470. doi: 10.1021/jacs.0c02949.
6. Ma G#, Liu J#, Ke Y#, Liu X, Huang Y, Li M, Wang Y*, Zhou Y*.(2018).Optogenetic Control of Voltage Gated Calcium Channels. Angew Chem Int Ed. 57(24):7019-7022.
7. Jing J#, He L#, Sun A#, Quintana A#, Ding Y#, Ma G, Tan P, Liang X, Zheng X, Chen L, Shi X, Zhang SL, Zhong L, Huang Y, Dong MQ, Walker CL, Hogan PG, Wang Y*, Zhou Y*. (2015) Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca2+ influx. Nat Cell Biol. 17(10):1339-47
8. Ma G#, Wei M#, He L#, Liu C#, Wu B, Zhang SL, Jing J, Liang X, Senes A, Tan P, Li S, Sun A, Bi Y, Zhong L, Si H, Shen Y, Li M, Lee MS, Zhou W, Wang J*, Wang Y*, Zhou Y*. (2015) Inside-out Ca2+ signalling prompted by STIM1 conformational switch. Nature Communications.6:7826 doi: 10.1038/ncomms8826
9. Wang X#, Wang Y#*, Zhou Y, Hendron E, Mancarella S, Andrake MD, Rothberg BS, Soboloff J, Gill DL*. (2014) Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site. Nature Communications. 5,3183.
10. Wang Y, Deng X, Mancarella S, Hendron E, Eguchi S, Soboloff J, Tang X and Gill DL. (2010) The calcium store-sensor, STIM1, reciprocally controls Orai and CaV1.2 channels. Science. 330(6000):105-9.
评论 (#: 共同第一作者；*: 共同通讯作者) ：
1. Jing J*, Zhou Y, Wang Y*. (2021) Dimming the donor to brighten up FRET-based biosensors. Cell Calcium. 99:102474. doi: 10.1016/j.ceca.2021.102474.
2. Ma G, Liu J, Zhou Y*, Wang Y* (2018) Let there be light: a bright future for Ca2+ signaling. Science Bulletin. 63 (2018) 1029–1031
3. Rothberg BS, Wang Y, and Gill DL (2013). Orai Channel Pore Properties and Gating by STIM: Implications from the Orai Crystal Structure. Science Signaling. 6(267):pe9.
4. Mancarella S, Wang Y, Gill DL. (2011) SIGNAL TRANSDUCTCTION STIM1 senses both Ca2+ and heat. Nature Chemical Biology. 7(6):344-5
5. Wang Y, Deng X, Gill DL. (2010) Calcium signaling by STIM and Orai: intimate coupling details revealed. Sci Signal. 3(148):pe42
6. Mancarella S, Wang Y, Gill DL. (2009) Calcium signals: STIM dynamics mediate spatially unique oscillations. Curr Biol. 19(20):R950-2.
